| Silph Co | Trainers | Items |
| South Exit: Saffron City The Silph Co. is a large skyscraper which houses Silph Co., the creators of Poké Balls in the region. Team Rocket take over the company at one point requiring you to go in and stop them. There are many items found within the building
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| 1F | 2F | 3F | 4F | 5F | |||||
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| 6F | 7F | 8F | 9F | 10F | |||||
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| Pokémon Trainer Blue | Exeggutor | Charizard | ||||
| Battle Type Items | Level 38 | Level 40 | ||||
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| Attacks: Power Whip Psychic Light Screen | Attacks: Heat Wave Slash Air Slash |
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| Ace Trainer Leopold | Kingler | ||||
| Battle Type Items | Level 75 | ||||
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| Attacks: Agility Stomp Scald Guillotine |
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| Master Trainer |
Items
| Pics | Item | Quantity | Method |
 | X Sp. Atk | 1 | Next to the fountains |
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| Team Rocket Grunt | Raticate | ||||
| Battle Type Items | Level 33 | ||||
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| Attacks: Sucker Punch Super Fang |
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| Team Rocket Grunt | Koffing | Koffing | Koffing | ||||
| Battle Type Items | Level 33 | Level 33 | Level 33 | ||||
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| Attacks: Clear Smog Sludge Self-Destruct Toxic | Attacks: Clear Smog Sludge Self-Destruct Toxic | Attacks: Clear Smog Sludge Self-Destruct Toxic |
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| Scientist Jerry | Electabuzz | ||||
| Battle Type Items | Level 35 | ||||
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| Attacks: Thunderbolt Swift |
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| Scientist Connor | Weezing | ||||
| Battle Type Items | Level 35 | ||||
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| Attacks: Sludge Bomb Shadow Ball |
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Items
| Pics | Item | Quantity | Method |
 | Super Potion | 1 | Between two gated areas in the left |
 | X Attack | 1 | In bottom right hand office |
| TM42 | 1 | From woman in top-left room |
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| Team Rocket Grunt | Haunter | ||||
| Battle Type Items | Level 33 | ||||
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| Attacks: Sucker Punch Shadow Ball |
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| Scientist Jose | Grimer | Magmar | ||||
| Battle Type Items | Level 35 | Level 35 | ||||
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| Attacks: Poison Jab | Attacks: Flamethrower Clear Smog |
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Items
| Pics | Item | Quantity | Method |
 | X Sp. Def | 1 | In office in the right |
 | Max Lure | 1 | Next to Scientist Jose in leftmost room |
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| Team Rocket Grunt | Koffing | Electrode | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Clear Smog Sludge Self-Destruct Toxic | Attacks: Thunder Shock Swift Self-Destruct Screech |
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| Team Rocket Grunt | Rattata | Grimer | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Quick Attack | Attacks: Toxic Sludge Bomb |
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| Scientist Rodney | Voltorb | Voltorb | Electrode | ||||
| Battle Type Items | Level 35 | Level 35 | Level 35 | ||||
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| Attacks: Light Screen Thunderbolt | Attacks: Thunderbolt Sonic Boom | Attacks: Thunderbolt Sonic Boom |
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| Black Belt Masahiro | Machop | ||||
| Battle Type Items | Level 65 | ||||
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| Attacks: Thunder Punch Poison Jab Bulk Up |
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| Master Trainer |
Items
| Pics | Item | Quantity | Method |
 | Dire Hit | 1 | In office in the bottom right |
 | Full Heal | 1 | In bottom-left room - Card Key Required |
 | Star Piece | 1 | In bottom-left room - Card Key Required |
 | Escape Rope | 1 | In bottom-left room - Card Key Required |
 | Great Ball | 1 | On shelves in bottom-left room - Card Key Required |
 | Revive | 1 | On shelves in bottom-left room - Card Key Required |
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| Juggler Dalton | Hypno | Haunter | Kadabra | ||||
| Battle Type Items | Level 34 | Level 34 | Level 34 | ||||
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| Attacks: Hypnosis Psychic Headbutt | Attacks: Dream Eater Sucker Punch Shadow Ball | Attacks: Night Shade Reflect Psybeam |
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| Pokémon Trainer Rival | Cubone | Pidgeot | Gloom | Jolteon | ||||
| Battle Type Items | Level 36 | Level 36 | Level 36 | Level 37 | ||||
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| Attacks: Focus Energy Bonemerang Headbutt | Attacks: Quick Attack Air Slash Sand Attack Roost | Attacks: Razor Leaf Toxic Acid | Attacks: Thunder Shock Quick Attack Pin Missile Double Kick |
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| Let's Go, Pikachu! |
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| Pokémon Trainer Rival | Cubone | Pidgeot | Gloom | Raichu | ||||
| Battle Type Items | Level 36 | Level 36 | Level 36 | Level 37 | ||||
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| Attacks: Focus Energy Bonemerang Headbutt | Attacks: Quick Attack Air Slash Sand Attack Roost | Attacks: Razor Leaf Toxic Acid | Attacks: Thunder Shock Quick Attack Thunder Punch Slam |
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| Let's Go, Eevee! |
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| Team Rocket Grunt | Muk | Raticate | ||||
| Battle Type Items | Level 34 | Level 34 | ||||
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| Attacks: Toxic Screech Minimize Protect | Attacks: Sucker Punch Quick Attack |
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| Team Rocket Admin Archer | Electrode | Golbat | Weezing | ||||
| Battle Type Items | Level 37 | Level 37 | Level 37 | ||||
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| Attacks: Self-Destruct Thunderbolt Swift | Attacks: Air Slash Crunch | Attacks: Sludge Bomb Flamethrower Dark Pulse Protect |
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| Scientist Beau | Muk | ||||
| Battle Type Items | Level 35 | ||||
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| Attacks: Minimize Ice Punch Thunder Punch Fire Punch |
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| Team Rocket Grunt | Ekans | Hypno | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Glare Poison Jab Slam Screech | Attacks: Poison Gas Meditate Psybeam Headbutt |
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| Team Rocket Grunt | Zubat | Arbok | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Haze Leech Life Toxic Air Slash | Attacks: Bite Haze Glare Poison Jab |
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Items
| Pics | Item | Quantity | Method |
 | Poke Ball | 3 | Defeat Juggler Dalton |
 | Card Key | 1 | Dropped by Team Rocket Grunt after defeating her and Archer |
 | Max Ether | 1 | In room with Scientist Beau |
| TM54 | 1 | In bottomleft room | |
| Poke Ball | 5 | In bottomleft room |
 | Guard Spec. | 1 | In middle server room - Card Key Required |
 | Nugget | 1 | In passageway on far right |
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| Team Rocket Grunt | Meowth | Raticate | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Fake Out Feint Play Rough | Attacks: Sucker Punch Super Fang Quick Attack |
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| Scientist Taylor | Magnemite | Magnemite | Magmar | ||||
| Battle Type Items | Level 35 | Level 35 | Level 35 | ||||
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| Attacks: Flash Cannon Thunderbolt | Attacks: Flash Cannon Thunderbolt | Attacks: Flamethrower Clear Smog |
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| Team Rocket Grunt | Raticate | Golbat | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Quick Attack Crunch | Attacks: Leech Life Confuse Ray Crunch |
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Items
| Pics | Item | Quantity | Method |
 | Max Repel | 1 | In the bottom left room - Card Key Required |
 | Hyper Potion | 1 | In the bottom left room - Card Key Required |
| Super Potion | 1 | By tree near Scientist Taylor |
| X Sp. Atk | 1 | Next to employee in main room |
 | PP Up | 1 | In corridor on far right |
| Anchors | Gift Pokémon |
| Max Spawns |
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| Lapras | |||||||||||||||||||||||||||||||
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| Team Rocket Grunt | Zubat | Golbat | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Haze Leech Life Toxic Air Slash | Attacks: Swift Confuse Ray Haze Leech Life |
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| Scientist Joshua | Koffing | Magneton | ||||
| Battle Type Items | Level 35 | Level 35 | ||||
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| Attacks: Sludge Bomb Dark Pulse | Attacks: Flash Cannon Tri Attack |
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| Team Rocket Grunt | Voltorb | Voltorb | Voltorb | ||||
| Battle Type Items | Level 33 | Level 33 | Level 33 | ||||
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| Attacks: Self-Destruct | Attacks: Self-Destruct | Attacks: Thunderbolt Swift |
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Items
| Pics | Item | Quantity | Method |
 | Rare Candy | 1 | In room with man who gives Lapras - Card Key Required |
| PP Up | 1 | Above Scientist Joshua |
| TM34 | 1 | Under desk in room to the right - Card Key Required | |
 | Smart Candy | 3 | In bottom right room - Card Key Required |
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| Team Rocket Grunt | Grimer | Koffing | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Minimize Disable Sludge Screech | Attacks: Clear Smog Sludge Self-Destruct Toxic |
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| Team Rocket Grunt | Gastly | Persian | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Shadow Ball Sucker Punch Will-O-Wisp Toxic | Attacks: Feint Slash Bite |
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| Scientist Parker | Electrode | Porygon | ||||
| Battle Type Items | Level 35 | Level 35 | ||||
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| Attacks: Reflect Sonic Boom | Attacks: Hyper Beam |
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Items
| Pics | Item | Quantity | Method |
| X Attack | 1 | In room on the right |
| Revive | 1 | In top left room |
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| Team Rocket Grunt | Persian | ||||
| Battle Type Items | Level 33 | ||||
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| Attacks: Feint Hypnosis Fake Out Play Rough |
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| Scientist Ed | Weezing | Electabuzz | Electrode | ||||
| Battle Type Items | Level 35 | Level 35 | Level 35 | ||||
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| Attacks: Toxic Protect Psybeam | Attacks: Thunder Punch Quick Attack | Attacks: Screech Thunderbolt |
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| Team Rocket Grunt | Koffing | Haunter | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Clear Smog Sludge Self-Destruct Toxic | Attacks: Will-O-Wisp Sucker Punch Toxic Shadow Ball |
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Items
| Pics | Item | Quantity | Method |
| Revive | 1 | Next to beds in the bottom left - Card Key Required |
| Great Ball | 3 | On shelves in bottom-middle room |
| Poke Ball | 3 | In bottom-middle room |
 | Ultra Ball | 3 | On shelves next to Scientist Ed |
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| Team Rocket Grunt | Voltorb | Raticate | ||||
| Battle Type Items | Level 33 | Level 33 | ||||
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| Attacks: Self-Destruct | Attacks: Quick Attack Crunch Sucker Punch |
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| Scientist Travis | Grimer | Muk | ||||
| Battle Type Items | Level 35 | Level 35 | ||||
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| Attacks: Poison Jab Fire Punch | Attacks: Poison Jab Ice Punch |
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Items
| Pics | Item | Quantity | Method |
| Full Heal | 1 | Next to table in top left |
 | Max Revive | 1 | In Bottom-left Room |
| Rare Candy | 1 | In Bottom-left Room |
| TM37 | 1 | In Bottom-left Room |
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| Team Rocket Grunt | Drowzee | Zubat | Golbat | ||||
| Battle Type Items | Level 33 | Level 33 | Level 33 | ||||
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| Attacks: Meditate Psybeam Headbutt Psychic | Attacks: Haze Leech Life Toxic Air Slash | Attacks: Swift Confuse Ray Haze Leech Life |
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| Team Rocket Jessie | Arbok | ||||
| Battle Type Items | Level 36 | ||||
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| Attacks: Poison Jab Glare Crunch Rock Slide |
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| Team Rocket James | Weezing | ||||
| Battle Type Items | Level 36 | ||||
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| Attacks: Sludge Bomb Dark Pulse Flamethrower Thunderbolt |
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| Team Rocket Boss Giovanni | Persian | Rhyhorn | Nidoqueen | ||||
| Battle Type Items | Level 39 | Level 39 | Level 39 | ||||
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| Attacks: Slash Feint Fake Out Play Rough | Attacks: Drill Run Take Down Megahorn Rock Throw | Attacks: Body Slam Crunch |
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| Lass Yumi | Wigglytuff | ||||
| Battle Type Items | Level 75 | ||||
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| Attacks: Sing Tri Attack Disable |
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| Master Trainer |
Items
| Pics | Item | Quantity | Method |
 | Max Elixir | 1 | On far right |
 | Master Ball | 1 | From Silph Co. President after removing Team Rocket |